Gene name:
MAP2K2 (MEK2;MKK2;PRKMK2) ;
Protein name:
Dual specificity mitogen-activated protein kinase kinase 2 (MAP kinase kinase 2;MAPKK 2) ;
Alternative:
MAPK/ERK kinase 2 (MEK 2) ;ERK activator kinase 2 ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Interacts with MORG1.
Function:
Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases.
Subcellular Location:
N/A
Protein Attributes:
50:
MLARRKPVLP | ALTINPTIAE | GPSPTSEGAS | EANLVDLQKK | LEELELDEQQ |
100:
KKRLEAFLTQ | KAKVGELKDD | DFERISELGA | GNGGVVTKVQ | HRPSGLIMAR |
150:
KLIHLEIKPA | IRNQIIRELQ | VLHECNSPYI | VGFYGAFYSD | GEISICMEHM |
200:
DGGSLDQVLK | EAKRIPEEIL | GKVSIAVLRG | LAYLREKHQI | MHRDVKPSNI |
250:
LVNSRGEIKL | CDFGVSGQLI | DSMANSFVGT | RSYMAPERLQ | GTHYSVQSDI |
300:
WSMGLSLVEL | AVGRYPIPPP | DAKELEAIFG | RPVVDGEEGE | PHSISPRPRP |
350:
PGRPVSGHGM | DSRPAMAIFE | LLDYIVNEPP | PKLPNGVFTP | DFQEFVNKCL |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Dog
Human
Mouse
Rat
Chicken
ELISA Kit for Human MAP kinase kinase 2
ELISA Kit for Human MAP kinase kinase 2
ELISA Kit for Human MAP kinase kinase 2
ELISA Kit for Human MAP kinase kinase 2
ELISA Kit for Human MAP kinase kinase 2
CLIA Kit for Human MAP kinase kinase 2
CLIA Kit for Human MAP kinase kinase 2
CLIA Kit for Human MAP kinase kinase 2
CLIA Kit for Human MAP kinase kinase 2
CLIA Kit for Human MAP kinase kinase 2
Polyclonal Antibody for Human MAP kinase kinase 2
Polyclonal Antibody for Human MAP kinase kinase 2
Polyclonal Antibody for Human MAP kinase kinase 2
Polyclonal Antibody for Human MAP kinase kinase 2
Polyclonal Antibody for Human MAP kinase kinase 2
Monoclonal Antibody for Human MAP kinase kinase 2
Monoclonal Antibody for Human MAP kinase kinase 2
Monoclonal Antibody for Human MAP kinase kinase 2
Monoclonal Antibody for Human MAP kinase kinase 2
Monoclonal Antibody for Human MAP kinase kinase 2
Protein for Human MAP kinase kinase 2
Protein for Human MAP kinase kinase 2
Protein for Human MAP kinase kinase 2
Protein for Human MAP kinase kinase 2
Protein for Human MAP kinase kinase 2
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue :
Muscle .
tissue :
Skin .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 40-51; 53-61; 64-100; 102-112; 164-172; 194-205; 265-297; 362-371 AND 389-397;PHOSPHORYLATION AT THR-394;IDENTIFICATION BY MASS SPECTROMETRY
tissue :
Colon carcinoma .
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 210-231;INACTIVATION BY YERSINIA YOPJ;PHOSPHORYLATION AT SER-222 AND SER-226;ACETYLATION AT SER-222 AND SER-226;IDENTIFICATION BY MASS SPECTROMETRY
5.
"Proteolytic inactivation of MAP-kinase-kinase by anthrax lethal factor."
Duesbery N.S.
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Webb C.P.
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Leppla S.H.
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Gordon V.M.
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Klimpel K.R.
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Copeland T.D.
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Vande Woude G.F.
Science280:734-737(1998)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : CLEAVAGE BY ANTHRAX LETHAL FACTOR
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : CLEAVAGE BY ANTHRAX LETHAL FACTOR
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Platelet .
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-293 AND SER-295;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-394 AND THR-396;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
12.
"Protein kinase SGK1 enhances MEK/ERK complex formation through the phosphorylation of ERK2: implication for the positive regulatory role of SGK1 on the ERK function during liver regeneration."
Won M.
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Park K.A.
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Byun H.S.
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Kim Y.R.
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Choi B.L.
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Hong J.H.
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Park J.
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Lee Y.H.
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Shen H.M.
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Hur G.M.
J. Hepatol.51:67-76(2009)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH SGK1
13.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
14.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Leukemic T-cell .
15.
"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V.
,
Vermeulen M.
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Santamaria A.
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Kumar C.
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Miller M.L.
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Jensen L.J.
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Sci. Signal.3:RA3-RA3(2010)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-295 AND THR-394;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
16.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
17.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-394 AND THR-396;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
18.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT CFC4 CYS-57
19.
"Mutation and phenotypic spectrum in patients with cardio-facio-cutaneous and Costello syndrome."
Schulz A.L.
,
Albrecht B.
,
Arici C.
,
van der Burgt I.
,
Buske A.
,
Gillessen-Kaesbach G.
,
Heller R.
,
Horn D.
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Hubner C.A.
,
Korenke G.C.
,
Konig R.
,
Kress W.
,
Kruger G.
,
Meinecke P.
,
Mucke J.
,
Plecko B.
,
Rossier E.
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Schinzel A.
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Schulze A.
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Seemanova E.
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Seidel H.
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Spranger S.
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Tuysuz B.
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Wieczorek D.
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more...
Clin. Genet.73:62-70(2008)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS CFC4 VAL-57 AND HIS-134
20.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT CFC4 GLN-128;CHARACTERIZATION OF VARIANT CFC4 GLN-128